Three protein complexes (the proteasome regulatory lid, the COP9 signalosome and eukaryotic translation initiation factor 3) contain protein subunits with a well defined protein domain, the PCI domain. At least two (the COP9 signalosome and the lid) appear to share a common evolutionary origin. Recent advances in our understanding of the structure and function of the three complexes point to intriguing and unanticipated connections between the cellular functions performed by these three protein assemblies, especially between translation initiation and proteolytic protein degradation.
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of gangliosides in the re-establishment of neuronal continuity was examined in rats whose peroneal nerve had been crushed by a standardized procedure. Neuronal continuity was determined by the ability of the nerve to transport horseradish peroxidase retrogradely back to the spinal Original Uggs Uk
cord. The number of retrogradely labeled neurons provided an index of the degree of axonal transport that was re-established. Comparison of ganglioside-treated animals with saline-treated controls showed that ganglioside treatment advanced the re-establishment of retrograde axonal transport by 3 days.